CD270 Antibody

• Catalog Number: orb1088492
• Category: Antibodies
• Description: CD270 is a type I transmembrane protein of the TNFR superfamily, which is expressed on resting T cells, monocytes, and immature dendritic cells. Its ligands, CD258 and CD272, differ in effect on CD270 signaling. Whereas binding to CD258 provides a costimulatory signal, binding to CD272 gives to the cell an inhibitory signal. CD270 also is recognized by herpes simplex glycoprotein D. CD258-CD270 interaction and signaling is implicated in macrophage-derived foam cell-mediated development of atherosclerotic lesions.
• Target: CD270
• Clonality: Monoclonal
• Isotype: Mouse IgG1 kappa
• Conjugation: Unconjugated
• Reactivity: Human
• Concentration: 1 mg/ml
• Buffer/Preservatives: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Purification: Purified by protein-A affinity chromatography.
• Immunogen: recombinant human CD270
• UniProt ID: Q92956
• Tested applications: ELISA, FC, ICC, IP, WB
• Application notes: Flow cytometry: Recommended dilution: 1-5 μg/ml.
• Antibody Type: Primary Antibody
• Clone Number: CW10
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: TNFRSF14, TR2, ATAR, HVEA, HVEM, LIGHTR
• Research Area: Epigenetics, Immunology, Infectious Diseases
• Note: For research use only
• Entrez: 8764

Separation of HDLM-2 cells stained using anti-CD270 (CW10) purified antibody (concentration in sample 1.6 μg/ml, GAM APC, red-filled) from HDLM-2 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).