Anti-CLDN6 Reference Antibody (IMAB027)

• Catalog Number: orb1818344
• Category: Antibodies
• Description: Recombinant Antibody
• Clonality: Monoclonal
• Tested applications: ELISA, FC
• Reactivity: Human
• Isotype: IgG1
• Antibody Type: Primary Antibody
• Concentration: 1mg/ml
• Form/Appearance: Purified monoclonal antibody supplied in PBS, pH 6.0, without preservative.This antibody is purified through a protein A column.
• Conjugation: Unconjugated
• MW: 144.42
• UniProt ID: P56747
• Protein Sequence: CLDN6
• Expression System: CHO Cell
• Endotoxins: < 0.001EU/μg,determined by LAL method.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Alternative names: Claudin-6, Skullin, CLDN6
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

The purity of Anti-CLDN6 Reference Antibody (IMAB027) is more than 98.41%, determined by SEC-HPLC.

Immobilized human CLDN6 VLP at 8 µg/mL can bind Anti-CLDN6 Reference Antibody (IMAB027), EC50=0.001599 µg/mL

Anti-CLDN6 Reference Antibody (IMAB027) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%

IMAB027 inhibited the tumor growth of OV90 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 50.7% at 5 mpk at D34.

Anti-CLDN6 Reference Antibody (IMAB027) -induced ADCC activity was evaluated using Human CD16a (158V) (Luc) Jurkat Reporter Cell. The max induction fold was approximately 14.16

Human CLDN6 CHO cells were stained with Anti-CLDN6 Reference Antibody (IMAB027) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC199=4.342 nM

Anti-CLDN6 Reference Antibody (IMAB027).by huCLDN6-HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 60% at antibody concentration of 1 nM.