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Anti-CLDN6 Reference Antibody (IMAB027)
Catalog Number: orb1806238
| Catalog Number | orb1806238 |
|---|---|
| Category | Antibodies |
| Description | Anti-CLDN6 Reference Antibody is expressed from CHO. It has a predicted MW of 145.5 kDa. |
| Clonality | Monoclonal |
| Tested applications | ELISA, FA, FACS, Kinetics |
| Reactivity | Human |
| Isotype | IgG |
| Purity | > 95% |
| Conjugation | Unconjugated |
| MW | 145.5 kDa |
| Target | CLDN6 |
| Endotoxins | < 1 EU/mg |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Buffer/Preservatives | 100 mM Pro-Ac 20 mM Arg pH 5.0 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Anti-CLDN6 Reference Antibody (IMAB027) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
The purity of Anti-CLDN6 Reference Antibody (IMAB027)is more than 98.41% ;determined by SEC-HPLC.
Immobilized human CLDN6 VLP at 8 μg/mL can bind Anti-CLDN6 Reference Antibody (IMAB027);EC50=0.001599μg/mL.
Human CLDN6 CHO cells were stained with Anti-CLDN6 Reference Antibody (IMAB027) and negative control protein respectively; washed and then followed by PE and analyzed with FACS; EC199=4.342 nM.
Anti-CLDN6 Reference Antibody (IMAB027)-induced ADCC activity was evaluated using Human CD16a (158V) (Luc) Jurkat Reporter Cell. The max induction fold was approximately 14.16
Anti-CLDN6 Reference Antibody (IMAB027);by huCLDN6-HEK293 increased with the increase of antibody concentration; and the Internalization Rate (%) reached 60% at antibody concentration of 1 nM.
IMAB027 inhibited the tumor growth of OV90 on Balb/c nude mice. The result showed significant anti-tumor effects; with an tumor inhibition rate (TGI) of 50.7% at 5 mpk at D34.
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