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ZLDI-8
Catalog Number: orb746527
| Catalog Number | orb746527 |
|---|---|
| Category | Small Molecules |
| Description | ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus; exhibits cytotoxic acitviity against MHCC97-H cells with IC50 of 5.32 uM, reduces the expression of pro-survival/anti-apoptosis regulators, Survivin and cIAP1/2, also increases the expression of epithelial marker E-Cadherin and reduces mesenchymal markers N-Cadherin and Vimentin in HCC cells; significantly disrupted the activity of Notch pathway in HCC cells and inhibits the epithelial-mesenchymal transition (EMT) process of HCC cells; ZLDI-8 treatment enhances the susceptibility of HCC cells to Sorafenib, Etoposide, and Paclitaxel both in vitro and in vivo. |
| CAS Number | [667880-38-8] |
| Purity | > 98%,Standard References |
| MW | 433.526 |
| SMILES | C(=S)1NC(=O)/C(=C/C2C3=C(N(CCOC4=CC=C(C)C=C4C)C=2C)C=CC=C3)/C(=O)N1 |
| Formula | C24H23N3O3S |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
ZLDI-8 [orb1308913]
98.09%
667880-38-8
433.52
C24H23N3O3S
5 mg, 1 mg, 50 mg, 1 ml x 10 mm (in DMSO), 100 mg, 25 mg, 10 mg
