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Catalog Number | orb1785885 |
---|---|
Category | Small Molecules |
Description | VY-3-135 is an orally active, selective acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 value of 44 nM. VY-3-135 displayes no inhibitory activity towards recombinant human ACSS1 or ACSS3. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. VY-3-135 inhibits triple negative breast cancer (TNBC) tumor growth in mouse ACSS2high but not ACSS2low tumors models. |
CAS Number | [1824637-41-3] |
MW | 429.51 |
SMILES | C1(C(O)(C2=CC=CC=C2)C2=CC=CC=C2)N(CC)C2=CC(C(NC[C@H](O)C)=O)=CC=C2N=1 |
Formula | C26H27N3O3 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
98.56% | |
1824637-41-3 | |
429.51 | |
C26H27N3O3 |
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