VEGF Receptor 2 Antibody / VEGFR2 / KDR

• Catalog Number: orb2644095
• Category: Antibodies
• Description: This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.
• Species/Host: Rat
• Clonality: Monoclonal
• Clone Number: DC101
• Tested applications: Blocking, NeA, WB
• Reactivity: Mouse
• Isotype: Rat IgG1, kappa
• Immunogen: Recombinant full-length Mouse VEGFR2 protein was used as the immunogen for this VEGFR2 antibody.
• Antibody Type: Primary Antibody
• Dilution range: Western blot (Non-reducing): 2-5ug/ml,Blocks binding of VEGF to VEGF-R2,Inhibits VEGF-induced signalingformat),Blocks tumor growth in mice
• Purity: Protein G affinity chromatography
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Hazard Information: This VEGFR2 antibody is available for research use only.
• UniProt ID: P35918
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
• Note: For research use only
• Application notes: Optimal dilution of the antibody should be determined by the researcher.
• Expiration Date: 12 months from date of receipt.

SDS-PAGE analysis of purified, BSA-free VEGFR2 antibody (clone DC101) as confirmation of integrity and purity.