Val-Cit-PAB-MMAE

SKU: orb1307265

Description

Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the protease-cleavable Val-Cit-PAB linker and the cytotoxic payload monomethyl auristatin E (MMAE). MMAE potently inhibits tubulin polymerization, disrupting mitosis. This conjugate is widely used in ADC research for targeted cancer therapy, enabling the evaluation of drug delivery and efficacy in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 644981-35-1
• MW: 1123.43
• Purity: 99.66% (May vary between batches)
• Formula: C₅₈H₉₄N₁₀O₁₂
• SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](N)C(C)C)cc1)C(C)C
• Target: PROTAC Linker,Drug-Linker Conjugates for ADC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.45 mM);DMSO:49 mg/mL (43.62 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Auristatin, DrugLinkerConjugatesforADC, Drug-Linker Conjugates for ADC, DrugLinker Conjugates for ADC, inhibit, Inhibitor, Val Cit PAB MMAE, ValCitPABMMAE, Val-Cit-PAB-MMAE

Compound Identifiers

PubChem CID

88914158