DBCO-Val-Cit-PAB-MMAE

SKU: orb3137002

Description

DBCO-Val-Cit-PAB-MMAE is a linker-toxin complex designed for the construction of antibody-drug conjugates (ADCs). It consists of a DBCO (dibenzocyclooctyne) click chemistry group, a protease-cleavable Val-Cit dipeptide linker, a p-aminobenzyl (PAB) self-cleaving spacer, and the microtubule inhibitor MMAE. DBCO-Val-Cit-PAB-MMAE can be conjugated to azide-containing biomolecules via a copper-free click reaction. Upon cleavage by lysosomal proteases within the cell, it releases MMAE, thereby inducing cell cycle arrest and cell death.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2768446-73-5
• MW: 1410.74
• Purity: 99.25% (May vary between batches)
• Formula: C₇₇H₁₀₇N₁₁O₁₄
• SMILES: C(CCC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(N([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(=O)N2[C@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)C3=CC=CC=C3)C)=O)C)OC)(CCC2)[H])OC)[C@H](CC)C)C)=O)C(C)C)=O)[C@@H](C)C)C)=O)C=C1)=O)CCCNC(N)=O)=O)[C@H](C)C)=O)(=O)N4C=5C(C#CC=6C(C4)=CC=CC6)=CC=CC5
• Target: Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Drug-Linker Conjugates for ADC