Urethane

SKU: orb1310989

Description

Urethane

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51-79-6
• MW: 89.09
• Purity: 99.63% (May vary between batches)
• Formula: C₃H₇NO₂
• SMILES: CCOC(N)=O
• Target: NMDAR,Parasite,Chloride channel,GluR,GABA Receptor,AChR,Antibacterial
• Solubility: DMSO:55 mg/mL (617.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (22.45 mM)

Bioactivity

• Target IC50:
  GABAA receptor:64 mM(EC50)|AMPA receptor:34 mM(EC50)|Glycine receptor:46 mM(EC50)|NMDAR:70 mM(EC50)|α4β2 nAChR:114 mM(EC50)
• In Vivo:
  Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity.
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• In Vitro:
  urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pesticide, Urethane, α4β2 nAChR, mutagen, inhibit, narcosis, NMDA receptor, Parasite, Ethyl carbamate, GABA Receptor, GABAReceptor, GABAR, Glycine receptor, Ethylurethane, Inhibitor, clastogen, Chloride channel, Chloridechannel, AMPA, Bacterial, carbamic, Carbamic acid ethyl ester, acid

Compound Identifiers

PubChem CID

5641