TRIM

SKU: orb1219789

Description

TRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM. TRIM (10-50 mg kg-1) administered i.p. exhibits dose-related antinociceptive activity in the mouse (assessed as inhibition of late phase formalin-induced hindpaw licking behaviour) with an ED50 of 85.8 mumol kg-1. In contrast, TRIM (50 mg kg-1, i.p.) failed to influence mean arterial blood pressure in the urethane-anaesthetized mouse.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 25371-96-4
• MW: 212.17
• Purity: >98% (HPLC)
• Formula: C₁₀H₇F₃N₂
• SMILES: FC(F)(F)c1ccccc1-n1ccnc1
• Target: NOS
• Solubility: In Vitro: DMSO : 250 mg/mL (1178.30 mM)

Bioactivity

• In Vitro:
  TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 μM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-(2-Trifluoromethylphenyl)imidazole

Quick Database Links

Gene Symbol

NOS