TSC2 antibody

• Catalog Number: orb67142
• Category: Antibodies
• Description: Rabbit polyclonal to TSC2.Tuberin (TSC2) forms a complex with TSC1 and inhibits the nutrient-mediated or growth factorstimulatedphosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling.TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of theprotein kinase activity of mTORC1. It is implicated as a tumor suppressor. TSC2 is involved inmicrotubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Defects in TSC2 causetuberous sclerosis type 2 (TSC2) and lymphangioleiomyomatosis (LAM).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: N-terminal region of human TSC2
• Dilution range: WB:1:500-1:1000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 201
• UniProt ID: P49815
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-TSC2 antibody,anti-Tuberin antibody,anti-Tube
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Hela(Lane1) and mouse MEF(Lane2) using TSC2 antibody