TSC2 antibody

• Catalog Number: orb106932
• Category: Antibodies
• Description: Rabbit polyclonal to TSC2. In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Clone Number: RB42286
• Tested applications: WB
• Predicted Reactivity: Mouse, Rat
• Reactivity: Human
• Isotype: Rabbit IgG
• Immunogen: Synthetic Peptide
• Dilution range: WB: 1:1000
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• MW: 200608
• Target: TSC2
• UniProt ID: P49815
• NCBI: NP_001070651.1, NP_001107854.1, NP_000539.2
• Alternative names: anti TSC2 antibody, anti TSC4 antibody, anti Tuber
• Note: For research use only
• Expiration Date: 12 months from date of receipt.