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Troponin C Protein, Human, Recombinant
Catalog Number: orb1955766
| Catalog Number | orb1955766 |
|---|---|
| Category | Proteins |
| Description | Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. |
| Tag | Tag Free |
| Purity | 98.00% |
| MW | 18.4 kDa (predicted); 20 kDa (reducing conditions) |
| UniProt ID | P63316 |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. |
| Expression Region | A DNA sequence encoding the human TNNC1 (NP_003271.1) (Met1-Glu161) was expressed and purified. Predicted N terminal: Ser 21 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Human TNNC2 protein [orb54352]
Greater than 90% as determined by SDS-PAGE.
45 kDa
E.coli
20 μg, 100 μg, 1 mg - Item 1 of 1
Human TNNC1 Protein [orb1476861]
Greater than 85% as determined by SDS-PAGE.
19.5 kDa
Baculovirus
1 mg, 20 μg, 100 μg - Item 1 of 1
Human TNNC1 Protein [orb1477059]
Greater than 90% as determined by SDS-PAGE.
21.0 kDa
E.coli
1 mg, 20 μg, 100 μg Human TNNC1 protein [orb707066]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
E. coli
500 μg, 50 μg, 10 μgTNNC1 Protein, Human, Recombinant (His) [orb1962169]
Greater than 95% as determined by reducing SDS-PAGE
17-20 KDa (reducing condition)
1 mg, 500 μg, 50 μg, 10 μg
