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TNNC1 Protein, Human, Recombinant (His)
Catalog Number: orb1962169
| Catalog Number | orb1962169 |
|---|---|
| Category | Proteins |
| Description | Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin I inhibits the calcium-dependent muscle contraction mediated by Troponins C and T. The expression of cardiac Troponin I (TNNI3) is restricted to cardiac muscle, while TNNI1 and TNNI2 (encoded by distinct genes) are expressed in skeletal muscle. Mutations of cardiac Troponin I are associated with heriditary cardiomyopathy. Human cardiac Troponin I shares 93% amino acid sequence identity with mouse and rat cardiac Troponin I. |
| Tag | N-6xHis |
| Purity | Greater than 95% as determined by reducing SDS-PAGE |
| MW | 17-20 KDa (reducing condition) |
| UniProt ID | P63316 |
| Protein Sequence | Met1-Glu161 |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin I inhibits the calcium-dependent muscle contraction mediated by Troponins C and T. The expression of cardiac Troponin I (TNNI3) is restricted to cardiac muscle, while TNNI1 and TNNI2 (encoded by distinct genes) are expressed in skeletal muscle. Mutations of cardiac Troponin I are associated with heriditary cardiomyopathy. Human cardiac Troponin I shares 93% amino acid sequence identity with mouse and rat cardiac Troponin I. |
| Expression Region | Met1-Glu161 |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 2
Recombinant human TNNI3 protein, His [orb1516897]
> 95% as determined by SDS-PAGE
34-35 kDa
500 μg, 100 μg - Item 1 of 1
Recombinant human TNIC (complex) protein, Trx & S & His [orb1516806]
> 95% as determined by SDS-PAGE
59.2 kDa
500 μg, 100 μg Human Troponin-C (His) Protein [orb429000]
Greater than 95% as determined by SDS-PAGE.
E.coli
2 μg, 10 μg, 1 mgHuman TNNI3 (His) Protein [orb428931]
Protein is > 95% pure as determined by 12% PAGE (coomassie staining).
Escherichia Coli
100 μg, 0.5 mg, 1 mgRecombinant Human TNNC1&TNNI3 Protein, His Tag [orb1553071]
≥90% as determined by SDS-PAGE
This protein contains the human TNNI3(Met1-Glu161 & Thr31-Arg111) was fused with the C-terminal His Tag and expressed in E. coli.
100 μg, 50 μg
