TRIM33 antibody

• Catalog Number: orb67253
• Category: Antibodies
• Description: Rabbit polyclonal to TRIM33.Tripartite motif-containing protein 33 (TRIM33) is a nuclear protein localized in discrete nuclear dotsresembling nuclear bodies. TRIM33 acts as an E3 ubiquitin-protein ligase, and promotes SMAD4ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. TRIM33 mayact as a transcriptional repressor of the TGF-beta/BMP signaling cascade. It is thought that TRIM33can monoubiquitinate SMAD4, which hampers its ability to form a stable complex with activatedSMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. TRIM33 plays a role in thecontrol of cell proliferation. Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: C-terminal region of human TRIM33
• Dilution range: WB:1:1000-1:3000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 123
• UniProt ID: Q9UPN9
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-TRIM33 antibody,anti-E3 ubiquitinprotein liga
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Jurkat(Lane1) and mouse thymus(Lane2) using TRIM33 antibody