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Catalog Number | orb1731247 |
---|---|
Category | Antibodies |
Description | Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines . |
Species/Host | Rabbit |
Clonality | Monoclonal |
Tested applications | IP, WB |
Reactivity | Human, Mouse, Rat |
Isotype | Rabbit IgG |
Immunogen | Recombinant protein of human TRIF |
Concentration | 1mg/ml |
Dilution range | IP: 1/20; WB: 1/500-1/1000 |
Conjugation | Unconjugated |
MW | Calculated MW: 76 kDa; Observed MW: 98 kDa |
Entrez | 148022 |
UniProt ID | Q8IUC6 |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Buffer/Preservatives | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% rAlbumin |
Alternative names | TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1 Read more... |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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