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Catalog Number | orb1962003 |
---|---|
Category | Proteins |
Description | Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
Tag | N, C-6xHis |
Purity | > 99.9% |
MW | 70-90 KDa (reducing condition) |
UniProt ID | P40225 |
Protein Sequence | Ser22-Gly353 |
Expression System | HEK293 Cells |
Biological Origin | Human |
Biological Activity | Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
Expression Region | Ser22-Gly353 |
Storage | -20°C |
Note | For research use only |
Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Expiration Date | 6 months from date of receipt. |
> 90% as determined by SDS-PAGE | |
27.4 kDa |
Greater than 85% as determined by SDS-PAGE. | |
Sf9, Insect cell |
> 97% by SDS-PAGE. | |
Recombinant Human Thrombopoietin/THPO Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Ser22-Gly353) of human Thrombopoietin/THPO (Accession #NP_000451.1) fused with a 6��His Tag at the C-terminus. |