TET2 (N2) Antibody, Rabbit Polyclonal

SKU: orb131790

Description

Rabbit polyclonal to TET2. TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 plays an important role in myelopoiesis, and defects in TET2 gene have been associated with several myeloproliferative disorders.

Research Area

Epigenetics

Images & Validation

• Tested Applications: ChIP, IF, IP, WB
• Dilution range: WB:1:1000-1:3000
• Reactivity: Mouse
• Application Notes:
  WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; ; Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of mouse TET2.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of mouse TET2
• Molecular Weight: 224
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Concentration: 100 μg/ml BSA
• Disclaimer: For research use only

Alternative Names

anti Methylcytosine dioxygenase TET2 antibody, anti KIAA1546 antibody

Quick Database Links

UniProt

Q4JK59

References

da Silva, Rodrigo A. et al. Laminar shear stress-provoked cytoskeletal changes are mediated by epigenetic reprogramming of TIMP1 in human primary smooth muscle cells J Cell Physiol, 234, 6382-6396 (2019)

PubMed: 30238981