Tat-βsyn-degron

• Catalog Number: orb1140647
• Category: Proteins
• Description: α-Synuclein knockdown peptide; Cell penetrating peptides.
• Modifications: None
• Structure: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Thr-Lys-Ser-Gly-Val-Tyr-Leu-Val-Gly-Arg-Arg-Arg-Gly-OH
• Target Areas: Protein-protein interactions, Proteasome
• Form/Appearance: Freeze fried solid
• Purity: > 95% by hplc
• MW: 3146.71 Da
• Formula: C₁₃₂H₂₃₇N₅₉O₃₁
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Thr-Lys-Ser-Gly-Val-Tyr-Leu-Val-Gly-Arg-Arg-Arg-Gly-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: PP040, Tat-βsyn-degron, Tat-βsyn-degron peptide, Y
• Background: Tat-βsyn-degron is ablood brain barrier and plasma membrane permeable α-synuclein knockdown peptide which can reduce the level ofα-synuclein by proteasomal degradation. Tat-βsyn-degrondecreases α-synuclein aggregates and microglial activation in an α-synuclein preformedfibril model of spreading synucleinopathy in transgenic mice overexpressing humanA53T α-synuclein, and reduces α-synuclein levels and significantlydecreases the neuronal damage and motor impairment in amouse toxicity model of Parkinsons disease.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.