Tat-NTS peptide

• Catalog Number: orb1140648
• Category: Proteins
• Description: Blocks the interaction of ANXA1 with importin β; Cell penetrating peptides.
• Modifications: C terminal amide.
• Structure: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
• Target Areas: Nuclear receptor modulators, Protein-protein interactions
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2855.4 Da
• Formula: C₁₂₅H₂₁₂N₅₄O₂₄
• Hazard Information: Non-Toxic
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: Tat-NTS , Tat-NTS peptide, YGRKKRRQRRRRSFPHLRRVF-N
• Background: Tat-NTS peptide is a cell-penetrating peptide consisting of Tat fused to amino acid residues R228 to F237 of the repeat III domain of ANXA1, which functions as a unique nuclear translocation signal (NTS). Tat-NTS peptide specifically blocks the interaction of ANXA1 with importin β and consequently the nuclear translocation of ANXA1. Tat-NTS peptide inhibits the transcriptional activity of p53, decreases Bid expression, suppresses activation of the caspase-3 apoptosis pathway and improves survival of neurons subjected to oxygen-glucose deprivation in vitro. In a focal brain ischemia animal model, Tat-NTS peptide reduces neuronal apoptosis in the ischemic zone and effects a dramatic reduction of infarct volume and a parallel improvement in neurological function after reperfusion.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.