TAT-Gap19

• Catalog Number: orb1140646
• Category: Proteins
• Description: Connexin43 hemichannel inhibitor; Cell penetrating peptides.
• CAS Number: 1507930-54-2
• Modifications: None
• Structure: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH
• Target Areas: Gap junction channels
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2703.28 Da
• Formula: C₁₁₉H₂₁₂N₄₆O₂₆
• Solubility (25°C): Soluble to 1 mg/ml in water
• Protein Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: , 1507930-54-2, TAT Gap19, TAT-Gap19, YGRKKRRQRRRK
• Background: TAT-Gap19 is a connexin43 (Cx43) hemichannel blocker, with an IC50 of 7 µM and no significant affinity for gap junctions or Panx1 channels. TAT-Gap19 is derived from Gap19, a sequence present on the intracellular cytoplasmic loop domain of Cx43, linked to the HIV-derived TAT internalization sequence to promote membrane permeability, which also allows brain penetration. In mouse models of liver damage, TAT-Gap19 can protect against liver fibrosis accompanied by superoxide dismutase overactivation and reduces production of inflammatory proteins.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Structure for TAT-Gap19