You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb1954944 |
---|---|
Category | Proteins |
Description | Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy. |
Tag | N-His |
Purity | 98.00% |
MW | 34.7 kDa (predicted) |
UniProt ID | O00560 |
Expression System | E. coli |
Biological Origin | Human |
Biological Activity | Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy. |
Expression Region | A DNA sequence encoding the human SDCBP (NP_001007068.1) (Met1-Val298) was expressed with a polyhistidine tag at the N-terminus. Predicted N terminal: Met |
Storage | -20°C |
Note | For research use only |
Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Expiration Date | 6 months from date of receipt. |
≥90% as determined by SDS-PAGE | |
This protein contains the human Sdcbp(Ser2-Val298) was fused with the C-terminal His Tag and expressed in E. coli. |