STING1 Antibody / TMEM173 / ERIS / MITA

• Catalog Number: orb1823325
• Category: Antibodies
• Description: TMEM173 (transmembrane protein 173), also called STING (Stimulator of interferon genes protein), ERIS and MITA, is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: STING1/7434
• Tested applications: IHC-P
• Reactivity: Human
• Isotype: Mouse IgG, kappa
• Immunogen: A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the Stimulator of interferon genes protein antibody.
• Dilution range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Hazard Information: This Stimulator of interferon genes protein antibody is available for research use only.
• UniProt ID: Q86WV6
• Storage: Aliquot the Stimulator of interferon genes protein antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

IHC staining of FFPE human tonsil tissue with Stimulator of interferon genes protein antibody (clone STING1/7434). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

SDS-PAGE analysis of purified, BSA-free Stimulator of interferon genes protein antibody (clone STING1/7434) as confirmation of integrity and purity.