Sotuletinib dihydrochloride

• Catalog Number: orb1910560
• Category: Small Molecules
• Description: Sotuletinib, also known as BLZ945, is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis.
• CAS Number: [2222138-40-9]
• MW: 471.397
• SMILES: O=C(NC)C1=NC=CC(OC2=CC=C3N=C(N[C@H]4[C@H](O)CCCC4)SC3=C2)=C1.[H]Cl.[H]Cl
• Formula: C₂₀H₂₄Cl₂N₄O₃S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.