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SDHB Antibody / Succinate dehydrogenase B

Catalog Number: orb1824503

DispatchUsually dispatched within 5-10 working days
$ 780.00
Catalog Numberorb1824503
CategoryAntibodies
DescriptionSuccinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
ClonalityMonoclonal
Species/HostMouse
IsotypeMouse IgG2, kappa
ConjugationUnconjugated
ReactivityHuman
ImmunogenA recombinant human SDHB protein fragment (within amino acids 165-273) was used as the immunogen for the SDHB antibody.
UniProt IDP21912
Tested applicationsIF, IHC-P
Dilution rangeImmunofluorescence: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Antibody TypePrimary Antibody
Clone NumberSDHB/3745
Formula1 mg/ml in 1X PBS; BSA free, sodium azide free
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Hazard InformationThis SDHB antibody is available for research use only.
NoteFor research use only
SDHB Antibody / Succinate dehydrogenase B

IHC staining of FFPE human liver tissue with SDHB antibody (clone SDHB/3745). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

SDHB Antibody / Succinate dehydrogenase B

SDS-PAGE analysis of purified, BSA-free SDHB antibody (clone SDHB/3745) as confirmation of integrity and purity.

  • SDHB Antibody / Succinate dehydrogenase B [orb1824504]

    IF,  IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg, 20 μg
  • SDHB Antibody / Succinate dehydrogenase B [orb1824506]

    IF,  IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg
  • SDHB Antibody / Succinate dehydrogenase B [orb1824507]

    IF,  IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    20 μg, 100 μg
  • SDHB Antibody / Succinate dehydrogenase B [orb1824551]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    100 μg
  • SDHB Antibody / Succinate dehydrogenase B [orb1824552]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    20 μg, 100 μg