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SCXA Antibody / Scleraxis
Catalog Number: orb2635844
| Catalog Number | orb2635844 |
|---|---|
| Category | Antibodies |
| Description | Transcription factors are proteins that bind DNA adjacent to genes and control the production of mRNA transcripts. Scleraxis (basic helix-loop-helix transcription factor scleraxis) is a 201 amino acid protein that dimerizes with another bHLH protein to initiate transcription. Scleraxis is known to play a role in formation of mesoderm and somite-derived chondrogenic lineages. Scleraxis localizes to the nucleus and contains one bHLH domain. bHLH transcription factors, in general, function in cellular differentiation, proliferation, and oncogene regulation. The gene encoding Scleraxis maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. |
| Clonality | Monoclonal |
| Species/Host | Mouse |
| Isotype | Mouse IgG2a |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant full-length human SCXA protein was used as the immunogen for the Scleraxis antibody. |
| UniProt ID | Q7RTU7 |
| Tested applications | FACS, IF |
| Dilution range | Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-3ug/ml |
| Application notes | Optimal dilution of the Scleraxis antibody should be determined by the researcher. |
| Antibody Type | Primary Antibody |
| Clone Number | PCRP-SCXA-1D2 |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This Scleraxis antibody is available for research use only. |
| Note | For research use only |
SDS-PAGE analysis of purified, BSA-free Scleraxis antibody (clone PCRP-SCXA-1D2) as confirmation of integrity and purity.
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