SATB1 antibody

• Catalog Number: orb66709
• Category: Antibodies
• Description: Rabbit polyclonal to SATB1.Special AT-rich sequence-binding protein 1 (SATB1) is a chromatin organizer and transcription factorthat integrates chromatin architecture with gene regulation. SATB1 binds to nuclear matrix/scaffoldassociatingAT-rich DNA sequences (MARs/SARs). It has been shown that SATB1 interacts withpromyelocytic leukemia protein (PML), and that SATB1 and PML function as a regulatory complexthat controls transcription by restructuring the dynamic chromatin-loop architecture. SATB1 isimplicated as a key regulator of the differentiation and activation of T cells. In cancer, SATB1 hasbeen shown to reprogram chromatin organization and the transcription profiles of breast tumors topromote growth and metastasis.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: N-terminal region of human SATB1
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 86
• UniProt ID: Q01826
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-SATB1 antibody,anti-OTTHUMP00000207689 antibo
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

Eleftheriadis, Theodoros et al. Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells Hum Immunol, 74, 1501-1509 (2013)

PubMed: 23993986

Western blot analysis of total cell extracts from mouse thymus using SATB1 antibody