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RRM1 Protein, Human, Recombinant (His & GST)
Catalog Number: orb1956414
| Catalog Number | orb1956414 |
|---|---|
| Category | Proteins |
| Description | RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. RRM1 may play a role in malignancies and disease that involve this region. |
| Tag | His, GST |
| UniProt ID | P23921 |
| MW | 117.9 kDa (predicted); 98 kDa (reducing conditions) |
| Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Expression System | Baculovirus Insect Cells |
| Biological Origin | Human |
| Expression Region | A DNA sequence encoding the human RRM1 (P23921) (Met1-Ser792) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. Predicted N terminal: Met |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 6 months from date of receipt. |
