RAF1 antibody

• Catalog Number: orb67278
• Category: Antibodies
• Description: Rabbit polyclonal to RAF1.RAF proto-oncogene serine/threonine-protein kinase AF1) belongs to the protein kinasesuperfamily. It acts as a regulatory link between the membrane-associated Ras GTPases and theMAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fatedecisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation.RAF1 can promote NF-kB activation and inhibit signal transducers involved in motility OCK2),apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis B1). It regulates Rhosignaling and migration, and is required for normal wound healing. Defects in RAF1 are the cause ofNoonan syndrome type 5 (NS5) and LEOPARD syndrome type 2 (LEOPARD2).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: N-terminal region of human RAF1
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 73
• UniProt ID: P04049
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-RAF1 antibody,anti-RAF protooncogene serine a
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from mouse brain(Lane1) and human 293T(Lane2) using RAF1 antibody