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PTPRU Antibody / Protein Tyrosine Phosphatase Receptor Type U
Catalog Number: orb1824533
| Catalog Number | orb1824533 |
|---|---|
| Category | Antibodies |
| Description | Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPa, PTPb, PTPg, PTPd, PTPe, PTPz, PTPk, PTPm and PTPy. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTPy, also known as PTPRU, FMI, PCP-2, PTP-J, PTPRO, PTP-PI, PTPPSI or GLEPP1, is a receptor-type PTP containing a transmembrane region, two intracellular tandem catalytic domains, and an extracellular region with Ig-like and fibronectin type III-like repeats and a MAM (meprin-A5 antigen-PTPm) domain. PTPy localizes to adheren junctions and is capable of binding and dephosphorylating b-catenin thereby functioning as a negative regulator of b-catenin signaling. In addition, PTPy may function as a tumor suppressor, as its expression is silenced in a variety of tumors via methylation of its promoter. |
| Clonality | Monoclonal |
| Species/Host | Mouse |
| Isotype | Mouse IgG2, kappa |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the PTPRU antibody. |
| UniProt ID | Q92729 |
| Tested applications | IHC-P |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Antibody Type | Primary Antibody |
| Clone Number | PTPRU/7616 |
| Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human prostate tissue with PTPRU antibody (clone PTPRU/7616). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free PTPRU antibody (clone PTPRU/7616) as confirmation of integrity and purity.
- Item 1 of 2
PTPRU Antibody / Protein Tyrosine Phosphatase Receptor Type U [orb1824534]
IHC-P
Human
Mouse
Monoclonal
Unconjugated
20 μg, 100 μg
