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SpeB Protein

SKU: orb1184789

Description

SpeB is derived from Streptococcus pyogenes. It is an important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. It also cleaves human IL1B precursor to form biologically active IL1B and can induce apoptosis in human monocytes and epithelial cells in vitro, reduces phagocytic activity in monocytic cells. Thus, it may play a role in bacterial colonization, invasion, and inhibition of wound healing.

Research Area

Protein Biochemistry

Images & Validation

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Key Properties

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Expression SystemE. coli
TargetSpeB
ReactivityBacteria
TagNative
Endotoxins1.0 EU per μg
ConjugationUnconjugated

Storage & Handling

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StorageThe product MUST be stored at -70°C or lower upon receipt. -70°C for 12 months under sterile conditions
Form/AppearanceLiquid
Buffer/Preservatives20 mM Tris, 500 mM NaCl, pH 7.0
Expiration Date6 months from date of receipt.
Dry Ice ShippingPlease note: This product requires shipment on dry ice. A dry ice surcharge will apply.
DisclaimerFor research use only

Alternative Names

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Streptopain,Exotoxin type B,Streptococcal cysteine proteinase

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Quality Guarantee

Quality Guarantee

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
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Available Sizes

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2000 U
$ 980.00
DispatchUsually dispatched within 5-10 working days
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