Sephin 1

SKU: orb1217437

Description

Sephin1 is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

Key Properties

• CAS Number: 951441-04-6
• MW: 196.64
• Purity: >98% (HPLC)
• Formula: C₈H₉ClN₄
• SMILES: NC(N)=N/N=C/c(cccc1)c1Cl
• Target: Phospholipase
• Solubility: DMSO:200mg/ml(1017.10mM; need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: C57BL/6J female mice immunized with MOG35-55/CFA to induce chronic EAE. Dosage: 4 mg/kg, 8 mg/kg. Administration: i.p.; daily for 35 days. Result: Significantly delayed clinical disease onset with both dosages, but to a greater extent with the 8 mg/kg treatment. Animal model: Five-week-old female FVB mice (intracerebrally with mouse-adapted RML prions). Dosage: 100 μg. Administration: i.p.; 3 times per week for 60 days, after 60 days of treatment, the treatment was reduced to two i.p. injections per week for another 20 days. Result: Significantly prolonged survival of prion-infected mice.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

lcerguastat | IFB-088

Quick Database Links

Gene Symbol

Phospholipase