Icerguastat

SKU: orb1298308

Description

Icerguastat

Research Area

Metabolism Research

Key Properties

• CAS Number: 951441-04-6
• MW: 196.64
• Purity: 99.67% (May vary between batches)
• Formula: C₈H₉ClN₄
• SMILES: C(=N/NC(=N)N)\C1=C(Cl)C=CC=C1
• Target: Phosphatase
• Solubility: DMSO:200 mg/mL (1017.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (25.43 mM)

Bioactivity

• In Vivo:
  In a mouse model of prion infection, intraperitoneal treatment with Sephin1 significantly prolonged survival of prion-infected mice. When combining Sephin1 with the neuroprotective drug metformin, the survival of prion-infected mice was also prolonged.
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• In Vitro:
  Sephin1 dose and time dependently reduced PrPSc in different neuronal cell lines which were persistently infected with various prion strains. In addition, prion seeding activity was reduced in Sephin1-treated cells. Importantly, we found that Sephin1 significantly overcame the endoplasmic reticulum (ER) stress induced in treated cells, as measured by lower expression of stress-induced aberrant prion protein.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

misfolding, inhibit, Inhibitor, IFB 088, IFB088, IFB-088, Icerguastat, eIF2α, lcerguastat, stress, sclerosis, Sephin-1, Sephin 1, Sephin1, phosphatase PPP1R15A, Phosphatase, prion, protein

Compound Identifiers

PubChem CID

9561611