Sennoside A

SKU: orb1310122

Description

Sennoside A (NSC-112929) is an anthraquinone glycoside laxative derived from rhubarb. It is widely used in pharmacological research to study colonic motility and secretion, serving as a model compound for investigating stimulant laxative mechanisms in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 81-27-6
• MW: 862.74
• Purity: 99.55% (May vary between batches)
• Formula: C₄₂H₃₈O₂₀
• SMILES: OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c5c(O)cc(cc45)C(O)=O)c4cc(cc(O)c4C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O
• Target: HIV Protease,MAO
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.83 mM);DMSO:135 mg/mL (156.48 mM)

Bioactivity

• Target IC50:
  MAO:17 μM
• In Vivo:
  LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.).
• In Vitro:
  Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine through regulating the spontaneous motility of colon. It mildly inhibits bovine serum monoamine oxidase with IC50 of 17 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC112929, NSC-112929, NSC 112929, inhibit, Inhibitor, HIVProtease, HIV Protease, HIV, MAO, Human immunodeficiency virus, Sennoside A

Compound Identifiers

PubChem CID

73111