Protirelin Acetate

SKU: orb1679910

Description

Protirelin Acetate is a synthetic form of thyrotropin-releasing hormone (TRH) that stimulates secretion of thyrotropin and prolactin from the anterior pituitary. It is widely used in neuroscience and endocrinology research to study hypothalamic-pituitary-thyroid axis function in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 120876-23-5
• MW: 452.46
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₂₂N₆O₄.3/2C₂H₄O₂
• SMILES: CC(=O)O.CC(=O)O.CC(=O)O.C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N.C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N
• Target: Thyroid hormone receptor(THR),Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.42 mM);H2O:50 mg/mL (110.51 mM)

Bioactivity

• In Vivo:
  Protirelin (TRH) is an ancient neuropeptide that emerged before the divergence of protostomes and deuterostomes, possibly playing a role in regulating postembryonic growth and reproduction. This study explores Protirelin's impact on body temperature, administering intraperitoneal doses of 1, 5, 10, and 20 mg/kg to male Wistar rats weighing 200-250 g. The findings reveal a dose-dependent, temporary increase in body temperature following Protirelin administration. However, thyroidectomized rats injected with 20 mg/kg of Protirelin did not experience a temperature rise, unlike their sham-operated counterparts. These observations indicate that thyroid hormone release may contribute to Protirelin's hyperthermic effect.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Endogenous Metabolite, EndogenousMetabolite, inhibit, TRF Acetate, TRH, TRH Acetate, TSH-RF Acetate, THR, Thyroid Hormone Receptor, Thyroid hormone receptor, Thyroid Hormone, Thyroid hormone receptor(THR), Thyroidhormonereceptor, Thyroidhormonereceptor(THR), Protirelin, Protirelin Acetate

Compound Identifiers

PubChem CID

138376494