Protirelin Acetate(24305-27-9 free base)

SKU: orb1300312

Description

Protirelin Acetate, the acetate salt of Thyroliberin (CAS 24305-27-9 free base), is a synthetic tripeptide hormone that potently stimulates the secretion of thyrotropin and prolactin. It is widely used in endocrine research for investigating hypothalamic-pituitary-thyroid axis function in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 25575-91-1
• MW: 422.44
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₂₆N₆O₆
• SMILES: O=C([C@@H](NC([C@@H]1CCC(N1)=O)=O)CC2=CN=CN2)N3[C@H](C(N)=O)CCC3.CC(O)=O
• Target: Thyroid hormone receptor(THR)
• Solubility: DMSO:27.5 mg/mL (65.1 mM)

Bioactivity

• In Vivo:
  Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin
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• Animal Research:
  Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lopremone Acetate, pGlu-His-Pro-NH2 Acetate, THR, Thyroid hormone receptor, Thyroid hormone, Thyroidhormonereceptor(THR), Thyroidhormonereceptor, Thyroliberin Acetate, Thyroid hormone receptor(THR), Protirelin Acetate(24305 27 9 free base), Protirelin Acetate(24305279 free base), Protirelin Acetate(24305-27-9 free base), Synthetic thyrotropin-releasing hormone Acetate, TRF Acetate, TRH Acetate

Compound Identifiers

PubChem CID

69031038