Phospho-HMGCR (Ser872) Rabbit Polyclonal Antibody

SKU: orb6191

Description

Phospho-HMGCR (Ser872) Rabbit Polyclonal Antibody

Research Area

Metabolism Research

Images & Validation

• Tested Applications: ELISA, FC, IF, IHC-Fr, IHC-P, WB
• Dilution Range: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/Test, ELISA=1:5000-10000
• Reactivity: Human, Mouse, Rabbit, Rat
• Predicted Reactivity: Bovine, Canine, Gallus, Porcine

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Immunogen: KLH conjugated Synthesised phosphopeptide derived from human HMGCR around the phosphorylation site of Ser872 NR(p-S)KI
• Target: HMGCR
• Molecular Weight: 97 kDa
• Purification: Affinity purified by Protein A
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Liquid
• Buffer/Preservatives: 0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol.
• Concentration: 1mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LDLCQ3; LGMDR28; MYPLG; HMG-CoAR; Red; 3H3M; HMDH_HUMAN; HMGCR; HMG-CoA reductase; 1.1.1.34; HMDH_MOUSE; HMDH_RAT; 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; hydroxymethylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); HMGCR (phospho-S872); p-HMGCR; phospho-HMGCR; HMGCR (phospho-Ser872)

Quick Database Links

Gene Symbol

HMGCR

UniProt

P04035

Melissa A. Babcook, Mahmut Akgul, Seunghee Margevicius, Gregory T. MacLennan, Pingfu Fu, Robert Abouassaly, Sanjay Gupta Ser‐486/491 phosphorylation and inhibition of AMPKα activity is positively associated with Gleason score, metastasis, and castration‐resistance in prostate cancer: A retrospective clinical study Prostate, 78, 10 (2018)

PubMed: 29577356

Applications

IHC

Reactivity

Human

Ge, Jian et al. Induction mechanism of cigarette smoke components (CSCs) on dyslipidemia and hepatic steatosis in rats Lipids Health Dis, 21, 117 (2022)

PubMed: 36348421

Applications

WB

Reactivity

Rat

Doddapattar, Prakash et al. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice Mol Nutr Food Res, 57, 1718-1728 (2013)

PubMed: 23650230

Applications

WB

Reactivity

Mouse