OTUD5 Antibody / DUBA

SKU: orb248139

Description

OTUD5 (ovarian tumor domain-containing 5), also called DUBA (Deubiquitinating enzyme A), is a product of the OTUD5 gene, and a suppressor of the innate immune response via its deubiquitinating activity. The Innate immune systems provide immediate but short-lived defense against infection identified by PRRs, or pattern recognition receptors. OTUD5 cleaves the lysine-63-linked polyubiquitin chains of TRAF3, causing it to dissociate from TBK1, thereby failing to stimulate IFN type 1 production and leading to a suppressed innate immune response.

Images & Validation

• Tested Applications: WB
• Dilution Range: Western blot: 2-5ug/ml
• Reactivity: Human, Mouse, Rat
• Application Notes:
  Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Immunogen: A recombinant protein fragment from the C-terminal region of human OTUD5 was used as the immunogen for this antibody.
• Purification: Protein A affinity chromatography
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.5 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only