Orexin 2 Receptor Agonist

SKU: orb1304456

Description

This small molecule OX2R agonist exhibits potent and selective activation of the orexin 2 receptor (EC50 = 23 nM), with a 70-fold selectivity over OX1R. It is a valuable research tool for studying orexin signaling in sleep/wake regulation, metabolism, and reward processing in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1796565-52-0
• MW: 586.7
• Purity: 99.43% (May vary between batches)
• Formula: C₃₂H₃₄N₄O₅S
• SMILES: S(NC1=CC(NCCNC(=O)C2=CC(C)=CC=C2)=CC=C1)(=O)(=O)C=3C=C(C=CC3OC)C4=CC(C(N(C)C)=O)=CC=C4
• Target: OX Receptor
• Solubility: DMSO:50 mg/mL (85.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.41 mM)

Bioactivity

• Target IC50:
  OX2 recepter:23 nM(EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HCRT Receptor, Hypocretin Receptor, Inhibitor, O2XR, inhibit, Orexin Receptor (OX Receptor), Orexin 2 Receptor Agonist, OX Receptor, OX2R, OXReceptor

Compound Identifiers

PubChem CID

91810287