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Orexin 2 Receptor Agonist 3

SKU: orb3027439

Description

Orexin 2 Receptor Agonist 3 is an orally active and brain-penetrant agonist of the orexin receptor 2 (OX2) with an EC50 value of 2.5 nM. This compound increases wakefulness in both orexin/ataxin-3 NT1 mouse models and healthy Beagle dogs. It is applicable for research related to narcolepsy.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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MW537.56
FormulaC27H29F2N7O3
SMILESFC1=C([C@H](C(NC2(C3)CC3(C)C2)=O)N(C4CC5(CC5)C4)C(CC6=C(C7=NN(C)N=N7)ON=C6)=O)C=C(F)C=C1
TargetOX Receptor

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information