Neuromedin (U25), human

SKU: orb2694829

Description

Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction. Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated roles in vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock. NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KDs = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction. NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.

Key Properties

• Target: others
• CAS Number: 312306-89-1
• MW: 3080.44
• Purity: ≥95%
• Formula: C₁₄₁H₂₀₃N₄₁O₃₈
• Protein Sequence: FRVDEEFQSPFASQSRGYFLFRPRN-NH2

Storage & Handling

• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

others