Meropenem

SKU: orb1223514

Description

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. (In Vitro):Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia.(In Vivo):Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 96036-03-2
• MW: 383.46
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₅N₃O₅S
• SMILES: O=C(C(N12)=C(S[C@@H]3CN[C@H](C(N(C)C)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
• Target: Antibiotic
• Solubility: Water: 8 mg/mL (20.86 mM); DMSO: 77 mg/mL (200.8 mM)

Bioactivity

• In Vivo:
  Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection. Animal model: Male Sprague-Dawley rats (250-350 g) induced acute necrotizing pancreatitis. Dosage: 60 mg/kg. Administration: Intraperitoneal injection; once. Result: Significantly reduced the incidence of pancreatic infection.
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• In Vitro:
  Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ICI 194660 | Merrem I.V. | SM-7338

Quick Database Links

Gene Symbol

Antibiotic