KYL acetate

SKU: orb1296459

Description

KYL acetate is a potent and selective EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM) that blocks EphA4-ephrin interactions. It demonstrates neuroprotective properties by preventing amyloid-β oligomer-induced synaptic dysfunction, spine loss, and LTP impairment in hippocampal models, supported by its stability in cell culture assays.

Research Area

Signal Transduction

Key Properties

• Target: Ephrin Receptor
• MW: 1525.78
• Purity: 99.75% (May vary between batches)
• Formula: C₇₆H₁₁₂N₁₄O₁₉
• SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@H]3N(CCC3)C([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56.CC(O)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KYL acetate(676657 00 4 free base), KYL acetate(676657004 free base), KYL acetate(676657-00-4 free base), EphA4, Ephrin Receptor, EphrinReceptor

Compound Identifiers

PubChem CID

169553465