Ivermectin

SKU: orb1309664

Description

Ivermectin (MK-933) is a research compound that acts as an agonist of glutamate-gated chloride channels (GluCls), leading to its well-characterized antiparasitic effects. It is widely used in in vitro and in vivo studies of parasitology and neuropharmacology to investigate ion channel function and anthelmintic mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 70288-86-7
• MW: 875.1
• Purity: >98%
• Formula: C₄₈H₇₄O₁₄ (B₁a form)
• SMILES: CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@H](C[C@@H]2OC)O[C@H]2[C@@H](C)\C=C\C=C3/CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O[C@H]5C[C@@H](C\C=C2/C)O[C@@]2(CC[C@H](C)[C@H](O2)C(C)C)C5)[C@]34O)O[C@@H](C)[C@@H]1O.CC[C@@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C\C=C(C)\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\C=C\C=C3/CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2
• Target: Antibiotic,P2X Receptor,Antibacterial,Parasite,Anti-infection,HIV Protease,GluCls,SARS-CoV,Mitophagy,Autophagy,HSV
• Solubility: Soluble in DMSO (40 mg/ml)

Bioactivity

• In Vivo:
  Intraperitoneal injection of Ivermectin (1.25-10 mg/kg) can reduce the consumption of alcohol and saccharin. For mice exposed to lethal doses of LPS, Ivermectin inhibits LPS-induced NF-kB translocation and enhances survival rates.
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• In Vitro:
  Ivermectin exhibits antiviral activity against HIV-1 and Dengue fever virus. It binds to a novel site on GABAA receptors in hippocampal embryonic neurons of mice, conformationally enhancing the affinity of the GABA binding site. In nematodes, the compound interacts with glutamate-gated chloride channels (GluCls), disrupting the regulation mediated by GluCl activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

22,23-Dihydro C076B1; MK-933

Compound Identifiers

PubChem CID

46936176