Selamectin

SKU: orb1303218

Description

Selamectin (UK-124114) is a macrocyclic lactone anthelmintic derived from ivermectin. It acts by potentiating glutamate- and GABA-gated chloride channels in parasitic nematodes, as demonstrated by its growth inhibitory effect at 0.1 μg/ml in Haemonchus contortus larval development assays. This compound is utilized in veterinary parasitology research and in vitro studies of anthelmintic mechanisms.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 220119-17-5
• MW: 769.96
• Purity: >99.99% (May vary between batches)
• Formula: C₄₃H₆₃NO₁₁
• SMILES: COC1CC(OC2C(C)\C=C\C=C3/COC4\C(=N\O)C(C)=CC(C(=O)OC5CC(C\C=C2/C)OC2(CCC(C)C(O2)C2CCCCC2)C5)C34O)OC(C)C1O
• Target: P-gp,Antibacterial,Chloride channel,Parasite
• Solubility: DMSO:90 mg/mL (116.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.29 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Parasite, inhibit, Multidrug resistance protein 1, MDR1, Inhibitor, ABCB1, Cl? Channels, CD243, Chloride channel, Chloride Channel, Chloridechannel, Cluster of differentiation 243, P-glycoprotein, Pgp, P-gp, P-gp (P-glycoprotein), Selamectin, UK-124114, UK124114, UK 124114

Compound Identifiers

PubChem CID

9918614