Human IL-13 R alpha 1 & IL-13 Protein, Tag Free & His Tag

SKU: orb3245056

Description

Interleukin-13 (IL-13) is a pleiotropic cytokine produced predominantly by T helper 2 (Th2) cells, mast cells, basophils, and group 2 innate lymphoid cells (ILC2s). IL-13 binds to the IL-13Rα1 subunit with low-to-moderate affinity to form an initial binary complex. This binary complex subsequently recruits the shared IL-4Rα chain to form a high-affinity heterodimeric Type II receptor complex (IL-4Rα/IL-13Rα1). The functional dimer triggers downstream intracellular signaling, primarily through the JAK/STAT6 pathway. IL-13 plays a central role in type 2 immune responses, driving IgE synthesis, goblet cell metaplasia, mucus overproduction, smooth muscle contraction, and tissue fibrosis. It is a critical driver of allergic diseases such as asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis.

Images & Validation

• Application Notes:
  This protein . The protein has a calculated MW of 42.2 kDa (IL13RA1) & 19.0 kDa (IL13). The protein migrates as 29-39 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Key Properties

• Expression System: HEK293
• Target: IL-13 R alpha 1 & IL-13
• Reactivity: Human
• Tag: Native | C-10×His
• Expression Region: Gly 22 - Thr 343 (IL13RA1) & Gly 35 - Asn 146 (IL13)
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated
• MW: 42.2 kDa (IL13RA1) & 19.0 kDa (IL13)
• Purity: 90%

Storage & Handling

• Storage: -20°C to -70°C for 12 months in lyophilized state. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IL-13 R alpha 1 & IL-13

RefSeq:P35225, P78552, IL13, IL13RA1