Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein

SKU: orb3158027

Description

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Research Area

Neuroscience

Images & Validation

• Application Notes:
  This protein carries no "tag". The protein has a calculated MW of 14.5 kDa.

Key Properties

• Expression System: E. coli
• Target: Alpha-Synuclein
• Reactivity: Human
• Tag: Native
• Expression Region: Met 1 - Ala 140
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated
• MW: 14.5 kDa
• Purity: 90%

Storage & Handling

• Storage: The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C. The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions. The sonicated fibril should be stored at -70°C for not more than 8 weeks
• Form/Appearance: Liquid
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Alpha-Synuclein

UniProt

P37840

RefSeq:P37840, A53