α-helical CRF 9-41 acetate

SKU: orb1296386

Description

This peptide acts as a competitive CRF2 receptor antagonist (K_B = 100 nM) and a partial agonist at the CRF1 receptor (EC₅₀ = 140 nM). It is a valuable research tool for investigating the distinct roles of CRF receptor subtypes in stress-related behaviors, anxiety, and feeding regulation in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Target: CRFR
• Purity: 97.38% (May vary between batches)
• SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)N)O.CC(=O)O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α-helical CRF 9-41 Acetate, α-helical CRF 9-41 acetate(90880-23-2 Free base), a-helical CRF 9-41 Acetate, a-helical CRF 9-41 acetate(90880-23-2 Free base), alpha-helical CRF 9-41 Acetate, CRF2, CRF1

Compound Identifiers

PubChem CID

171361668