EGR2 (C) Antibody, Rabbit Polyclonal

SKU: orb131906

Description

Rabbit polyclonal to EGR2. E3 SUMO-protein ligase EGR2 belongs to the EGR C2H2-type zinc-finger protein family. EGR2 is a sequence-specific DNA-binding transcription factor and binds to two specific DNA sites located in the promoter region of HOXA4. EGR2 helps SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Defects in EGR2 are a cause of congenital hypomyelination neuropathy (CHN), of Charcot-Marie-Tooth disease type 1D (CMT1D), and of Dejerine-Sottas syndrome (DSS).

Research Area

Neuroscience

Images & Validation

• Tested Applications: ChIP, IP, WB
• Dilution Range: WB:1:1000-1:3000,IF/ICC:1:100-1:200
• Reactivity: Human, Mouse
• Application Notes:
  WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; ; Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human EGR2.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human EGR2
• Molecular Weight: Predicted M.W.: 50kDa, Observed M.W.: 60 kDa
• Purity: Affinity purification
• Purification: Purified by affinity purification using immunogen.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 1 x PBS (pH 7.4), 100 ug/ml rAlbumin, 40% Glycerol, 0.01% NaN3
• Concentration: 100 μg/ml BSA
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti E3 SUMO-protein ligase EGR2 antibody, anti AT591 antibody, anti Early growth response protein 2 antibody, anti Zinc finger protein Krox-20 antibody, anti EGR-2 antibody, anti KROX20 antibody

Quick Database Links

UniProt

P11161

Chengyun Xu et al. Early growth response 2 as a target of IL-13/STAT6 signaling induces the goblet cell metaplasia of allergic airway epithelia Allergol Int, (2026)

PubMed: 41708397

Applications

IP

Reactivity

Human