Bassoon Antibody (Biotin)

SKU: orb152185

Description

Rabbit polyclonal to Bassoon (Biotin). Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors..

Research Area

Disease Biomarkers, Neuroscience

Images & Validation

• Tested Applications: IHC, WB
• Dilution Range: WB (1:1000), IHC (1:400)
• Reactivity: Human, Mouse, Rat
• Application Notes:
  1 µg/ml was sufficient for detection of Bassoon in 10 µg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein
• Target: Bassoon
• Molecular Weight: 420kDa
• Purification: Protein A Purified
• Conjugation: Biotin

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate.
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bassoon, BSN, ZNF231, Zinc finger protein 231, Neuronal double zinc finger protein, KIAA0434

Quick Database Links

Gene Symbol

Bassoon

UniProt

Q9UPA5

NCBI Gene ID

8927

RefSeq (Protein):NP_003449.2